Genetic analysis of Shudderer, the lithium-responsive neurological mutant of Drosophila melanogaster
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چکیده
Approved: ________________________________ Thesis Supervisor ________________________________ Title and Department ________________________________ Date 1 GENETIC ANALYSIS OF SHUDDERER, THE LITHIUM-RESPONSIVE NEUROLOGICAL MUTANT OF DROSOPHILA MELANOGASTER by Garrett Anthony Kaas A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Genetics in the Graduate College of The University of Iowa
منابع مشابه
Lithium-Responsive Seizure-Like Hyperexcitability Is Caused by a Mutation in the Drosophila Voltage-Gated Sodium Channel Gene paralytic
Shudderer (Shu) is an X-linked dominant mutation in Drosophila melanogaster identified more than 40 years ago. A previous study showed that Shu caused spontaneous tremors and defects in reactive climbing behavior, and that these phenotypes were significantly suppressed when mutants were fed food containing lithium, a mood stabilizer used in the treatment of bipolar disorder (Williamson, 1982). ...
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